Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96H55
UPID:
MYO19_HUMAN
Alternative names:
Myosin head domain-containing protein 1
Alternative UPACC:
Q96H55; Q59GS4; Q9H5X2
Background:
Unconventional myosin-XIX, also known as Myosin head domain-containing protein 1, is a motor molecule with ATPase activity that is crucial for mitochondrial inheritance during mitosis. It localizes to the mitochondrion outer membrane and moves towards the plus-end of actin filaments, playing a significant role in mitochondrial transport or positioning.
Therapeutic significance:
Understanding the role of Unconventional myosin-XIX could open doors to potential therapeutic strategies.