Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96I45
UPID:
TM141_HUMAN
Alternative names:
-
Alternative UPACC:
Q96I45; A6NIZ7; Q5T5R5
Background:
Transmembrane protein 141 (TMEM141) is a protein of interest within the scientific community, characterized by its transmembrane nature. Despite its identification, the specific functions of TMEM141 remain to be fully elucidated. Its presence in cellular membranes suggests a potential role in cellular processes or signaling pathways.
Therapeutic significance:
Understanding the role of Transmembrane protein 141 could open doors to potential therapeutic strategies. The exploration of TMEM141's function and mechanism of action is crucial for identifying novel drug targets, particularly in diseases where cellular signaling or membrane dynamics are disrupted.