Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96KC2
UPID:
ARL5B_HUMAN
Alternative names:
ADP-ribosylation factor-like protein 8
Alternative UPACC:
Q96KC2
Background:
ADP-ribosylation factor-like protein 5B, alternatively known as ADP-ribosylation factor-like protein 8, plays a crucial role in cellular processes through its ability to bind and exchange GTP and GDP. This protein is pivotal in the regulation of a variety of cellular functions, including intracellular trafficking and signal transduction.
Therapeutic significance:
Understanding the role of ADP-ribosylation factor-like protein 5B could open doors to potential therapeutic strategies. Its involvement in fundamental cellular processes suggests that targeting this protein could offer new avenues for treating diseases with a cellular basis.