Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96LB3
UPID:
IFT74_HUMAN
Alternative names:
Capillary morphogenesis gene 1 protein; Coiled-coil domain-containing protein 2
Alternative UPACC:
Q96LB3; Q3B789; Q5VY34; Q6PGQ8; Q9H643; Q9H8G7
Background:
Intraflagellar transport protein 74 homolog (IFT74) is a pivotal component of the intraflagellar transport complex B, crucial for ciliogenesis and spermatogenesis. It partners with IFT81 to form a tubulin-binding module, facilitating tubulin transport within the cilium. IFT74's interaction with beta-tubulin underscores its essential role in cellular structures and processes.
Therapeutic significance:
IFT74's involvement in Bardet-Biedl syndrome 22, Joubert syndrome 40, and Spermatogenic failure 58 highlights its potential as a therapeutic target. Understanding IFT74's function could pave the way for innovative treatments for these genetic disorders, offering hope for affected individuals.