Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96LT4
UPID:
SAMD8_HUMAN
Alternative names:
Ceramide phosphoethanolamine synthase; Sterile alpha motif domain-containing protein 8
Alternative UPACC:
Q96LT4; Q5JSC5; Q5JSC8; Q66K52
Background:
Sphingomyelin synthase-related protein 1, also known as Ceramide phosphoethanolamine synthase or Sterile alpha motif domain-containing protein 8, plays a pivotal role in sphingolipid metabolism. It is an endoplasmic reticulum (ER) transferase that, unlike sphingomyelin synthases, specializes in the conversion of phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE), albeit with low efficiency. This protein acts as a ceramide sensor in the ER, crucial for maintaining ceramide homeostasis and ensuring the integrity of the early secretory pathway.
Therapeutic significance:
Understanding the role of Sphingomyelin synthase-related protein 1 could open doors to potential therapeutic strategies, particularly in managing diseases where sphingolipid metabolism is disrupted.