Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96P09
UPID:
BIRC8_HUMAN
Alternative names:
Inhibitor of apoptosis-like protein 2; Testis-specific inhibitor of apoptosis
Alternative UPACC:
Q96P09; Q6IPY1; Q96RW5
Background:
Baculoviral IAP repeat-containing protein 8, also known as Inhibitor of apoptosis-like protein 2 and Testis-specific inhibitor of apoptosis, plays a crucial role in cellular survival mechanisms. Its primary function is to protect against apoptosis mediated by BAX, a pro-apoptotic protein. This protection is vital for cell longevity and preventing premature cell death.
Therapeutic significance:
Understanding the role of Baculoviral IAP repeat-containing protein 8 could open doors to potential therapeutic strategies. Its ability to inhibit apoptosis positions it as a key target for developing treatments aimed at diseases where cell survival is compromised.