Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96P31
UPID:
FCRL3_HUMAN
Alternative names:
Fc receptor homolog 3; IFGP family protein 3; Immune receptor translocation-associated protein 3; MAIA; SH2 domain-containing phosphatase anchor protein 2
Alternative UPACC:
Q96P31; A0N0M4; A8MTH7; D3DVD2; Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30
Background:
Fc receptor-like protein 3, also known as Fc receptor homolog 3, plays a pivotal role in immune regulation. It promotes TLR9-induced B-cell proliferation and survival, while inhibiting antibody production. This protein also modulates NF-kappa-B and MAPK signaling pathways in B-cells, and has a unique role in sperm-egg adhesion and fusion during fertilization by interacting with the IZUMO1-IZUMO1R/JUNO sperm-egg complex.
Therapeutic significance:
Given its involvement in Rheumatoid arthritis, a disease with autoimmune features affecting the joints, Fc receptor-like protein 3 presents a promising target for therapeutic intervention. Understanding its regulatory mechanisms could lead to novel treatments for autoimmune diseases and fertility disorders.