Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96QF7
UPID:
GCNA_HUMAN
Alternative names:
Acidic repeat-containing protein; Germ cell nuclear acidic peptidase; Germ cell nuclear antigen
Alternative UPACC:
Q96QF7; B9EG62
Background:
The Germ cell nuclear acidic protein, also known as Acidic repeat-containing protein, Germ cell nuclear acidic peptidase, and Germ cell nuclear antigen, plays a crucial role in maintaining genomic stability. It is instrumental in the clearance of DNA-protein cross-links (DPCs) through a SUMO-dependent recruitment to sites of DPCs, safeguarding germ cells and early embryos from damage. This protein is particularly adept at resolving topoisomerase II (TOP2A) DPCs, highlighting its significance in cellular repair mechanisms.
Therapeutic significance:
Linked to Spermatogenic failure, X-linked, 4, a male infertility disorder characterized by non-obstructive azoospermia or oligoasthenoteratozoospermia, the Germ cell nuclear acidic protein's understanding could pave the way for innovative therapeutic strategies. Its role in ensuring genomic stability by protecting germ cells suggests potential in treating infertility issues.