Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96R05
UPID:
RET7_HUMAN
Alternative names:
Cellular retinoic acid-binding protein 4; Cellular retinoic acid-binding protein IV
Alternative UPACC:
Q96R05; B2R517; Q5SWJ4
Background:
Retinoid-binding protein 7, also known as Cellular retinoic acid-binding protein 4 or Cellular retinoic acid-binding protein IV, plays a crucial role in the intracellular transport of retinol. This protein is pivotal in the metabolism and function of retinoids, which are vital for vision, growth, and cellular differentiation.
Therapeutic significance:
Understanding the role of Retinoid-binding protein 7 could open doors to potential therapeutic strategies. Its involvement in the retinol transport system highlights its importance in cellular processes and its potential as a target for drug discovery in diseases where retinoid metabolism and function are compromised.