Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96SF7
UPID:
TBX15_HUMAN
Alternative names:
T-box transcription factor TBX14
Alternative UPACC:
Q96SF7; Q08E76; Q5JT54; Q5T9S7
Background:
T-box transcription factor TBX15, alternatively known as TBX14, plays a crucial role in skeletal development, particularly in the limbs, vertebral column, and head. It regulates the balance between mesenchymal precursor cells and chondrocytes, essential for proper bone and cartilage formation.
Therapeutic significance:
Cousin syndrome, characterized by unique skeletal abnormalities and potential intellectual impairment, is directly linked to variants in the TBX15 gene. Understanding the role of T-box transcription factor TBX15 could open doors to potential therapeutic strategies for this condition.