Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q99674
UPID:
CGRE1_HUMAN
Alternative names:
Cell growth regulatory gene 11 protein; Hydrophobestin
Alternative UPACC:
Q99674; A6NHV7; B4DXY8; B5MCB7; B5MCC9; B5MCP5; E7EU99; Q8N4B7
Background:
Cell growth regulator with EF hand domain protein 1, also known as Hydrophobestin, plays a crucial role in mediating cell-cell adhesion in a calcium-dependent manner. Its alternative name, Cell growth regulatory gene 11 protein, hints at its potential in regulating cell proliferation.
Therapeutic significance:
Understanding the role of Cell growth regulator with EF hand domain protein 1 could open doors to potential therapeutic strategies. Its ability to inhibit growth in several cell lines positions it as a key target for drug discovery efforts aimed at controlling unchecked cell proliferation.