Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
Q99788
UPID:
CML1_HUMAN
Alternative names:
Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ
Alternative UPACC:
Q99788; A8K6Y5; O75748; Q3KP37; Q5U0H0; Q99789
Background:
Chemerin-like receptor 1, also known as Chemokine-like receptor 1, G-protein coupled receptor ChemR23, and G-protein coupled receptor DEZ, plays a pivotal role in mediating cellular responses to chemoattractant adipokine chemerin/RARRES2 and omega-3 fatty acid derived molecule resolvin E1. This interaction triggers a cascade of signaling pathways, including G(i)/G(o), beta-arrestin, intracellular calcium mobilization, and phosphorylation of key enzymes, facilitating diverse biological effects such as immune response modulation, adipogenesis, and angiogenesis.
Therapeutic significance:
Understanding the role of Chemerin-like receptor 1 could open doors to potential therapeutic strategies.