Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BRC7
UPID:
PLCD4_HUMAN
Alternative names:
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4
Alternative UPACC:
Q9BRC7; Q53FS8
Background:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4, also known as Phospholipase C-delta-4, plays a pivotal role in cellular processes by hydrolyzing PIP2 to produce DAG and IP3. These molecules are crucial for the activation of PKC and the release of Ca(2+) from intracellular stores, respectively. This protein is essential for the acrosome reaction in sperm, cell growth, and liver regeneration through its interaction with nuclear PKC and modulation of the Erk signaling pathway.
Therapeutic significance:
Understanding the role of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 could open doors to potential therapeutic strategies.