Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BRT9
UPID:
SLD5_HUMAN
Alternative names:
GINS complex subunit 4
Alternative UPACC:
Q9BRT9; B2R8H5; D3DSY0; Q8N648
Background:
The DNA replication complex GINS protein SLD5, also known as GINS complex subunit 4, is pivotal for the GINS complex function. This complex is crucial in initiating DNA replication and ensuring the progression of DNA replication forks. It forms a core component of the CDC45-MCM-GINS (CMG) helicase, an essential molecular machine that unwinds DNA during replication, facilitating the construction of the replisome.
Therapeutic significance:
Understanding the role of DNA replication complex GINS protein SLD5 could open doors to potential therapeutic strategies.