Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9BSY9
UPID:
DESI2_HUMAN
Alternative names:
Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Protein FAM152A
Alternative UPACC:
Q9BSY9; B1APK6; Q5VVC6; Q9NYS2; Q9Y3E4
Background:
Deubiquitinase DESI2, also known as Desumoylating isopeptidase 2, PPPDE peptidase domain-containing protein 1, and Protein FAM152A, exhibits deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. It specifically deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7, leading to its stabilization, a process crucial for protein homeostasis and cellular functions.
Therapeutic significance:
Understanding the role of Deubiquitinase DESI2 could open doors to potential therapeutic strategies. Its unique ability to regulate protein stability through deubiquitination positions it as a key player in cellular homeostasis and disease mechanisms.