Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BTP7
UPID:
FAP24_HUMAN
Alternative names:
Fanconi anemia-associated protein of 24 kDa
Alternative UPACC:
Q9BTP7; B3KY46; Q8WUJ7; Q96FX6
Background:
Fanconi anemia core complex-associated protein 24, alternatively known as Fanconi anemia-associated protein of 24 kDa, plays a crucial role in DNA repair. It facilitates the recruitment of the FA core complex to sites of damaged DNA, regulating FANCD2 monoubiquitination in response to DNA damage. This protein is pivotal in maintaining chromosomal stability and modulating sensitivity to DNA cross-linking agents.
Therapeutic significance:
Understanding the role of Fanconi anemia core complex-associated protein 24 could open doors to potential therapeutic strategies. Its involvement in DNA repair mechanisms highlights its potential as a target for developing treatments aimed at enhancing DNA repair pathways, crucial for combating diseases characterized by genetic instability.