Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BUK0
UPID:
CHCH7_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BUK0; A8K223; E9PBH3; J3KNE9; Q7Z588
Background:
The Coiled-coil-helix-coiled-coil-helix domain-containing protein 7, encoded by the gene with the accession number Q9BUK0, plays a pivotal role in cellular architecture and signaling pathways. Its unique structural motif suggests a specialized function in cellular processes, potentially acting as a scaffold for protein-protein interactions.
Therapeutic significance:
Understanding the role of Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 could open doors to potential therapeutic strategies. Its involvement in critical cellular functions hints at its importance in maintaining cellular integrity, making it a target of interest for drug discovery efforts.