Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BV10
UPID:
ALG12_HUMAN
Alternative names:
Asparagine-linked glycosylation protein 12 homolog; Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase; Mannosyltransferase ALG12 homolog; Membrane protein SB87
Alternative UPACC:
Q9BV10; A6PWM1; Q4KMH4; Q8NG10; Q96AA4
Background:
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase, also known as Asparagine-linked glycosylation protein 12 homolog, plays a pivotal role in protein glycosylation. It is responsible for adding the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor, a critical step in the N-glycosylation pathway.
Therapeutic significance:
The protein is linked to Congenital disorder of glycosylation 1G, a multisystem disorder impacting embryonic development and cell functions. Understanding the role of Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase could open doors to potential therapeutic strategies for this and related glycosylation disorders.