Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BV40
UPID:
VAMP8_HUMAN
Alternative names:
Endobrevin
Alternative UPACC:
Q9BV40; O60625; Q53SP9; Q6IB09
Background:
Vesicle-associated membrane protein 8 (VAMP8), also known as Endobrevin, plays a pivotal role in cellular processes, including autophagy, membrane fusion, and secretion. It is integral in the formation of the trans-SNARE complex, facilitating the fusion of autophagosomes with lysosomes, and is crucial for dense-granule secretion in platelets and enzyme secretion in pancreatic acinar cells. Additionally, VAMP8 is involved in cell division, endosome fusion, and activating the type I interferon antiviral response.
Therapeutic significance:
Understanding the role of Vesicle-associated membrane protein 8 could open doors to potential therapeutic strategies.