Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BVA1
UPID:
TBB2B_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BVA1; A8K068
Background:
Tubulin beta-2B chain, a pivotal component of microtubules, plays an essential role in cellular structure and function. This protein is involved in the assembly of microtubules, critical for cell division, intracellular transport, and cellular morphology. Its significance extends to neuronal migration and axon guidance, highlighting its crucial role in neural development.
Therapeutic significance:
The association of Tubulin beta-2B chain with Cortical dysplasia, complex, with other brain malformations 7, underscores its therapeutic potential. Understanding the role of Tubulin beta-2B chain could open doors to potential therapeutic strategies for treating complex cortical malformations.