Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BW92
UPID:
SYTM_HUMAN
Alternative names:
Threonyl-tRNA synthetase; Threonyl-tRNA synthetase-like 1
Alternative UPACC:
Q9BW92; Q53GW7; Q96I50; Q9H9V2
Background:
Threonine--tRNA ligase, mitochondrial, also known as Threonyl-tRNA synthetase, plays a crucial role in protein synthesis. It catalyzes the attachment of threonine to tRNA(Thr), a fundamental process for accurate translation and protein production. This enzyme operates in a two-step reaction, ensuring the fidelity of protein synthesis by also editing incorrectly charged tRNA(Thr).
Therapeutic significance:
Linked to Combined oxidative phosphorylation deficiency 21, a severe mitochondrial disorder, Threonine--tRNA ligase's dysfunction underscores its importance in cellular energy metabolism. Understanding the role of Threonine--tRNA ligase could open doors to potential therapeutic strategies for mitochondrial diseases.