Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BX79
UPID:
STRA6_HUMAN
Alternative names:
Retinol-binding protein receptor STRA6; Stimulated by retinoic acid gene 6 protein homolog
Alternative UPACC:
Q9BX79; A8K7F1; B7Z5M9; B7Z862; D3DW54; F5GYI8; I3L1G8; Q6PJF8; Q71RB9; Q7L9G1; Q7Z3U9; Q8TB21; Q9BX78; Q9H9U8
Background:
Receptor for retinol uptake STRA6, also known as Retinol-binding protein receptor STRA6, plays a pivotal role in vitamin A homeostasis. It facilitates the transport of retinol across cell membranes, contributing to vital processes in the eye and under conditions of dietary vitamin A deficiency. STRA6's interaction with retinol-binding proteins and its involvement in signaling pathways underscore its importance in cellular responses to insulin and vitamin A metabolism.
Therapeutic significance:
STRA6's link to Microphthalmia, syndromic, 9, a condition characterized by severe eye formation disorders and pulmonary abnormalities, highlights its therapeutic potential. Understanding the role of STRA6 could open doors to potential therapeutic strategies for treating or managing this rare disease.