Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BXB1
UPID:
LGR4_HUMAN
Alternative names:
G-protein coupled receptor 48
Alternative UPACC:
Q9BXB1; A6NCH3; G5E9B3; Q8N537; Q9NYD1
Background:
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) plays a pivotal role in the canonical Wnt signaling pathway, essential for organ development including liver, kidney, and bone. Unlike typical G-protein coupled receptors, LGR4 does not activate heterotrimeric G-proteins but instead facilitates Wnt signal transduction, influencing gene expression and cellular processes.
Therapeutic significance:
LGR4's involvement in diseases like Osteoporosis and its role in bone formation and remodeling highlight its potential as a target for therapeutic intervention. Understanding the function of LGR4 could lead to novel treatments for skeletal disorders and delayed puberty, leveraging its regulatory effects on bone density and reproductive development.