Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BXM7
UPID:
PINK1_HUMAN
Alternative names:
BRPK; PTEN-induced putative kinase protein 1
Alternative UPACC:
Q9BXM7; Q8N6T9; Q8NBU3; Q96DE4
Background:
Serine/threonine-protein kinase PINK1, mitochondrial, also known as BRPK or PTEN-induced putative kinase protein 1, plays a pivotal role in protecting against mitochondrial dysfunction during cellular stress. It achieves this by phosphorylating mitochondrial proteins such as PRKN and DNM1L, coordinating mitochondrial quality control mechanisms. These mechanisms include removing and replacing dysfunctional mitochondrial components, preventing apoptosis, stimulating mitochondrial biogenesis, regulating mitochondrial dynamics, and eliminating severely damaged mitochondria via mitophagy.
Therapeutic significance:
PINK1's involvement in Parkinson disease 6, an early-onset form of Parkinson's characterized by parkinsonian signs and mitochondrial dysfunction, underscores its therapeutic significance. Understanding the role of PINK1 could open doors to potential therapeutic strategies targeting mitochondrial quality control mechanisms, offering hope for patients with Parkinson's and possibly other neurodegenerative disorders.