Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BXP8
UPID:
PAPP2_HUMAN
Alternative names:
Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1
Alternative UPACC:
Q9BXP8; A9Z1Y8; Q96PH7; Q96PH8; Q9H4C9
Background:
Pappalysin-2, also known as Pregnancy-associated plasma protein A2 (PAPP-A2), plays a crucial role in the regulation of insulin-like growth factor (IGF) by specifically cleaving insulin-like growth factor binding protein (IGFBP)-5. This action modulates the availability of IGF, a key factor in cellular growth and development.
Therapeutic significance:
The protein's involvement in Short stature, Dauber-Argente type, a disorder characterized by growth failure and altered serum levels of IGF components, highlights its potential as a target for therapeutic intervention. Understanding the role of Pappalysin-2 could open doors to potential therapeutic strategies.