Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BXU0
UPID:
TEX12_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BXU0; A6NDL9; B0YIX3
Background:
Testis-expressed protein 12 plays a crucial role in the formation of synaptonemal complexes during meiotic prophase, facilitating chromosome pairing and recombination. Its interaction with SYCP1 is essential for its incorporation into the central element, highlighting its significance in genetic stability and fertility.
Therapeutic significance:
Understanding the role of Testis-expressed protein 12 could open doors to potential therapeutic strategies.