Focused On-demand Library for E3 ubiquitin-protein ligase TRIM34

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Several key aspects differentiate our library:

Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.

partner

Reaxense

upacc

Q9BYJ4

UPID:

TRI34_HUMAN

Alternative names:

Interferon-responsive finger protein 1; RING finger protein 21

Alternative UPACC:

Q9BYJ4; D3DQS7; Q9C016; Q9HCR0; Q9HCR1; Q9HCR2

Background:

E3 ubiquitin-protein ligase TRIM34, also known as Interferon-responsive finger protein 1 and RING finger protein 21, plays a pivotal role in antiviral defense. It functions by targeting viral capsids, aiding in the restriction of non-host-adapted retroviruses, and promoting programmed cell death during influenza A virus infection. Additionally, TRIM34 is involved in mitochondrial regulation, apoptosis, and the formation of multinucleated giant cells in epithelial tissues.

Therapeutic significance:

Understanding the role of E3 ubiquitin-protein ligase TRIM34 could open doors to potential therapeutic strategies. Its involvement in antiviral defense mechanisms and cell apoptosis pathways highlights its potential as a target for developing treatments against viral infections and diseases associated with cell proliferation.