Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BYX4
UPID:
IFIH1_HUMAN
Alternative names:
Clinically amyopathic dermatomyositis autoantigen 140 kDa; Helicase with 2 CARD domains; Interferon-induced with helicase C domain protein 1; Melanoma differentiation-associated protein 5; Murabutide down-regulated protein; RIG-I-like receptor 2; RNA helicase-DEAD box protein 116
Alternative UPACC:
Q9BYX4; Q2NKL6; Q6DC96; Q86X56; Q96MX8; Q9H3G6
Background:
Interferon-induced helicase C domain-containing protein 1, also known as MDA5, plays a pivotal role in the innate immune response. It acts as a cytoplasmic sensor of viral nucleic acids, triggering antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. MDA5 detects a wide range of viruses, from Picornaviridae family members to coronaviruses like SARS-CoV-2, highlighting its critical role in viral infection defense mechanisms.
Therapeutic significance:
MDA5's involvement in diseases such as Type 1 diabetes mellitus, Aicardi-Goutieres syndrome, Singleton-Merten syndrome, and Immunodeficiency 95 underscores its therapeutic potential. Understanding the role of MDA5 could open doors to potential therapeutic strategies, offering hope for treatments targeting these conditions by modulating the innate immune response.