Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BZJ3
UPID:
TRYD_HUMAN
Alternative names:
Delta-tryptase; HmMCP-3-like tryptase III; Mast cell mMCP-7-like; Tryptase-3
Alternative UPACC:
Q9BZJ3; O95824; Q8TDI6; Q96L36; Q96RZ5; Q9H2Y6; Q9UQI8
Background:
Tryptase delta, also known as Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, and Tryptase-3, is the predominant neutral protease in mast cells, released during the activation-degranulation response. This enzyme plays a crucial role in the body's immune response by participating in the breakdown of proteins.
Therapeutic significance:
Understanding the role of Tryptase delta could open doors to potential therapeutic strategies. Its involvement in the immune system's response mechanisms suggests a potential for targeting in various inflammatory conditions and allergic reactions.