Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9BZK7
UPID:
TBL1R_HUMAN
Alternative names:
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
Alternative UPACC:
Q9BZK7; D3DNQ9; Q14DC3; Q9H2I1; Q9H9A1
Background:
F-box-like/WD repeat-containing protein TBL1XR1, also known as Nuclear receptor corepressor/HDAC3 complex subunit TBLR1, plays a pivotal role in transcription activation mediated by nuclear receptors. It acts as an essential component of the N-Cor corepressor complex, facilitating the recruitment of the 19S proteasome complex, leading to proteasomal degradation of the N-Cor complex, thereby enabling cofactor exchange and transcription activation.
Therapeutic significance:
TBL1XR1 is implicated in Pierpont syndrome and Intellectual developmental disorder, autosomal dominant 41, diseases characterized by developmental delays, learning disabilities, and distinctive physical features. Understanding the role of TBL1XR1 could open doors to potential therapeutic strategies for these conditions.