Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9C035
UPID:
TRIM5_HUMAN
Alternative names:
RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5
Alternative UPACC:
Q9C035; A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; Q2MLW6; Q2MLW7; Q2MLX1; Q2MLX2; Q2MLX3; Q2MLX5; Q2MLY3; Q2MLY4; Q2V6Q6; Q6GX26; Q8WU46; Q96SR5; Q9C031; Q9C032; Q9C033; Q9C034
Background:
Tripartite motif-containing protein 5, also known as RING finger protein 88 or RING-type E3 ubiquitin transferase TRIM5, plays a pivotal role in the innate immune response against retroviral infections. It acts as a capsid-specific restriction factor, blocking viral replication early in the life cycle. This protein recognizes and binds to the retroviral capsid, activating innate immune signaling through its E3 ubiquitin ligase activity, leading to the induction of NF-kappa-B and MAPK-responsive inflammatory genes.
Therapeutic significance:
Understanding the role of Tripartite motif-containing protein 5 could open doors to potential therapeutic strategies.