Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9C093
UPID:
SPEF2_HUMAN
Alternative names:
Protein KPL2
Alternative UPACC:
Q9C093; Q2TAC9; Q96LL6; Q9H5C7; Q9H5Q7
Background:
Sperm flagellar protein 2, also known as Protein KPL2, plays a pivotal role in male fertility. It is essential for the correct development of the axoneme in spermatozoa, crucial for sperm motility and morphology. This protein is involved in the localization of the intraflagellar transport protein IFT20, indicating its role in dynein-mediated protein transport during spermatogenesis. Additionally, it contributes to bone growth by supporting normal osteoblast differentiation.
Therapeutic significance:
Sperm flagellar protein 2 is linked to Spermatogenic failure 43, an autosomal recessive infertility disorder characterized by asthenospermia due to various sperm flagella abnormalities. Understanding the role of Sperm flagellar protein 2 could open doors to potential therapeutic strategies for treating infertility issues related to sperm motility and morphology.