Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9C0A1
UPID:
ZFHX2_HUMAN
Alternative names:
Zinc finger homeodomain protein 2
Alternative UPACC:
Q9C0A1; Q9UPU6
Background:
Zinc finger homeobox protein 2, alternatively known as Zinc finger homeodomain protein 2, plays a pivotal role in the regulation of pain perception and the processing of noxious stimuli. Its unique structure enables it to function as a transcriptional regulator, orchestrating the expression of genes critical for sensory responses.
Therapeutic significance:
The protein's association with Marsili syndrome, a condition marked by congenital pain insensitivity, underscores its therapeutic significance. Understanding the role of Zinc finger homeobox protein 2 could open doors to potential therapeutic strategies for managing pain and sensory disorders.