Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9C0E8
UPID:
LNP_HUMAN
Alternative names:
ER junction formation factor lunapark
Alternative UPACC:
Q9C0E8; B7ZLA8; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5
Background:
Endoplasmic reticulum junction formation protein lunapark, also known as ER junction formation factor lunapark, is pivotal in shaping the endoplasmic reticulum (ER) morphology. It stabilizes nascent three-way ER tubular junctions, contributing to the ER network's structure and is implicated in central nervous system development and limb development by similarity.
Therapeutic significance:
Linked to the neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum, understanding the role of Endoplasmic reticulum junction formation protein lunapark could open doors to potential therapeutic strategies.