Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9GZN4
UPID:
BSSP4_HUMAN
Alternative names:
Serine protease 22; Serine protease 26; Tryptase epsilon
Alternative UPACC:
Q9GZN4; O43342; Q6UXE0
Background:
Brain-specific serine protease 4, also known as Serine protease 22, Serine protease 26, and Tryptase epsilon, exhibits a unique preference for cleaving the synthetic substrate H-D-Leu-Thr-Arg-pNA over tosyl-Gly-Pro-Arg-pNA. This specificity highlights its distinct enzymatic activity within the serine protease family, suggesting a specialized role in biological processes.
Therapeutic significance:
Understanding the role of Brain-specific serine protease 4 could open doors to potential therapeutic strategies. Its unique substrate specificity indicates a precise biological function, which, once elucidated, may reveal novel targets for drug development.