Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9GZQ4
UPID:
NMUR2_HUMAN
Alternative names:
G-protein coupled receptor FM-4; G-protein coupled receptor TGR-1
Alternative UPACC:
Q9GZQ4; Q7LC54; Q96AM5; Q9NRA6
Background:
Neuromedin-U receptor 2, identified by the accession number Q9GZQ4, is a pivotal protein that functions as a receptor for neuromedin-U and neuromedin-S neuropeptides. Known alternatively as G-protein coupled receptor FM-4 and G-protein coupled receptor TGR-1, it plays a crucial role in various physiological processes.
Therapeutic significance:
Understanding the role of Neuromedin-U receptor 2 could open doors to potential therapeutic strategies. Its involvement in signaling pathways offers a promising avenue for the development of novel treatments.