Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H081
UPID:
MIS12_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H081; Q96N24
Background:
Protein MIS12 homolog is a crucial component of the MIS12 complex, vital for chromosome alignment, segregation, and kinetochore formation during mitosis. Its role is pivotal in ensuring proper kinetochore microtubule attachments, a fundamental process for accurate cell division.
Therapeutic significance:
Understanding the role of Protein MIS12 homolog could open doors to potential therapeutic strategies. Its critical function in cell division underscores its potential as a target in diseases characterized by abnormal cell proliferation.