Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H081
UPID:
MIS12_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H081; Q96N24
Background:
Protein MIS12 homolog is a crucial component of the MIS12 complex, vital for chromosome alignment, segregation, and kinetochore formation during mitosis. Its role is pivotal in ensuring proper kinetochore microtubule attachments, a fundamental process for accurate cell division.
Therapeutic significance:
Understanding the role of Protein MIS12 homolog could open doors to potential therapeutic strategies. Its critical function in cell division underscores its potential as a target in diseases characterized by abnormal cell proliferation.