Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H082
UPID:
RB33B_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H082; B2R987; Q4W5B0
Background:
Ras-related protein Rab-33B plays a pivotal role in protein transport, specifically in coordination with RAB6A to regulate intra-Golgi retrograde trafficking. It also modulates autophagosome formation, highlighting its importance in autophagy. This protein's involvement in critical cellular processes underscores its significance in maintaining cellular homeostasis.
Therapeutic significance:
Ras-related protein Rab-33B is linked to Smith-McCort dysplasia 2, a rare autosomal recessive osteochondrodysplasia characterized by short limbs, trunk with barrel-shaped chest, and distinctive skeletal abnormalities without affecting intelligence. Understanding the role of Ras-related protein Rab-33B could open doors to potential therapeutic strategies for treating this condition.