Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H1D9
UPID:
RPC6_HUMAN
Alternative names:
DNA-directed RNA polymerase III subunit F; RNA polymerase III 39 kDa subunit
Alternative UPACC:
Q9H1D9; A8K4C7; O15319
Background:
DNA-directed RNA polymerase III subunit RPC6, also known as the 39 kDa subunit, plays a crucial role in the transcription of DNA into RNA, focusing on small RNAs like 5S rRNA and tRNAs. It is pivotal in sensing and limiting infections by intracellular bacteria and DNA viruses, including varicella zoster virus. This protein binds preferentially to double-stranded DNA, detecting AT-rich DNA involved in the innate immune response.
Therapeutic significance:
The association of this protein with Immunodeficiency 101, a disorder characterized by reactivation of varicella zoster virus, underscores its therapeutic significance. Understanding the role of DNA-directed RNA polymerase III subunit RPC6 could open doors to potential therapeutic strategies for managing this immunologic disorder.