Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H2K2
UPID:
TNKS2_HUMAN
Alternative names:
ADP-ribosyltransferase diphtheria toxin-like 6; Poly [ADP-ribose] polymerase 5B; Protein poly-ADP-ribosyltransferase tankyrase-2; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein
Alternative UPACC:
Q9H2K2; B2RBD3; Q9H8F2; Q9HAS4
Background:
Poly [ADP-ribose] polymerase tankyrase-2, also known as TNKS-2, plays a pivotal role in cellular processes including the Wnt signaling pathway, telomere length regulation, and vesicle trafficking. It activates the Wnt signaling pathway through poly-ADP-ribosylation of AXIN1 and AXIN2, leading to their degradation and subsequent pathway activation. Additionally, TNKS-2's involvement in telomere length regulation and 26S proteasome activity underscores its multifunctional nature.
Therapeutic significance:
Understanding the role of Poly [ADP-ribose] polymerase tankyrase-2 could open doors to potential therapeutic strategies.