Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H4A6
UPID:
GOLP3_HUMAN
Alternative names:
Coat protein GPP34; Mitochondrial DNA absence factor
Alternative UPACC:
Q9H4A6; Q9UIW5
Background:
Golgi phosphoprotein 3, also known as Coat protein GPP34 and Mitochondrial DNA absence factor, is a pivotal phosphatidylinositol-4-phosphate-binding protein. It plays a crucial role in linking Golgi membranes to the cytoskeleton, facilitating vesicle budding, and maintaining the Golgi apparatus's structure. Its involvement extends to Golgi membrane trafficking, secretion regulation, and the modulation of mTOR signaling, highlighting its significance in cellular processes.
Therapeutic significance:
Understanding the role of Golgi phosphoprotein 3 could open doors to potential therapeutic strategies.