Focused On-demand Library for Speckle targeted PIP5K1A-regulated poly(A) polymerase

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.

Several key aspects differentiate our library:

  • Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
  • The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
  • Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
  • In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.







Alternative names:

RNA-binding motif protein 21; U6 snRNA-specific terminal uridylyltransferase 1

Alternative UPACC:

Q9H6E5; A1A527; A8K995; Q2NL65; Q7L583; Q9H6H7


The Speckle targeted PIP5K1A-regulated poly(A) polymerase, also known as RNA-binding motif protein 21 and U6 snRNA-specific terminal uridylyltransferase 1, plays a pivotal role in mRNA processing. It is responsible for the polyadenylation of specific pre-mRNAs, a crucial step in mRNA maturation and regulation. This enzyme localizes to nuclear speckles, working alongside PIP5K1A to selectively polyadenylate mRNAs like HMOX1. Beyond polyadenylation, it is essential for pre-mRNA 3'-end cleavage, facilitating the CPSF complex assembly on pre-mRNAs for accurate mRNA processing.

Therapeutic significance:

Understanding the role of Speckle targeted PIP5K1A-regulated poly(A) polymerase could open doors to potential therapeutic strategies.

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