Focused On-demand Library for N-alpha-acetyltransferase 60

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We employ our advanced, specialised process to create targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.







Alternative names:

Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F

Alternative UPACC:

Q9H7X0; B3KRQ0; B4DLZ0; B4DPZ8; B4DYC4; D3DUC2; E7EQ65; Q6IA31; Q6UX26


N-alpha-acetyltransferase 60, also known as Histone acetyltransferase type B protein 4, N-acetyltransferase 15, and N-alpha-acetyltransferase F, plays a pivotal role in protein modification. It specializes in the acetylation of N-terminal residues of transmembrane proteins, favoring those facing the cytosol. This enzyme exhibits specificity towards sequences starting with Met-Lys, Met-Val, Met-Ala, and Met-Met, and is essential for proper chromosomal segregation during anaphase. While its potential histone acetyltransferase activity is suggested, further evidence is required to confirm this function in vivo.

Therapeutic significance:

Understanding the role of N-alpha-acetyltransferase 60 could open doors to potential therapeutic strategies.

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