Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H7X0
UPID:
NAA60_HUMAN
Alternative names:
Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F
Alternative UPACC:
Q9H7X0; B3KRQ0; B4DLZ0; B4DPZ8; B4DYC4; D3DUC2; E7EQ65; Q6IA31; Q6UX26
Background:
N-alpha-acetyltransferase 60, also known as Histone acetyltransferase type B protein 4, N-acetyltransferase 15, and N-alpha-acetyltransferase F, plays a pivotal role in protein modification. It specializes in the acetylation of N-terminal residues of transmembrane proteins, favoring those facing the cytosol. This enzyme exhibits specificity towards sequences starting with Met-Lys, Met-Val, Met-Ala, and Met-Met, and is essential for proper chromosomal segregation during anaphase. While its potential histone acetyltransferase activity is suggested, further evidence is required to confirm this function in vivo.
Therapeutic significance:
Understanding the role of N-alpha-acetyltransferase 60 could open doors to potential therapeutic strategies.