Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H8M7
UPID:
MINY3_HUMAN
Alternative names:
Dermal papilla-derived protein 5; Deubiquitinating enzyme MINDY-3; Protein CARP
Alternative UPACC:
Q9H8M7; Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4
Background:
Ubiquitin carboxyl-terminal hydrolase MINDY-3, also known as Dermal papilla-derived protein 5, Deubiquitinating enzyme MINDY-3, and Protein CARP, plays a crucial role in protein degradation pathways. It specifically targets 'Lys-48'-linked ubiquitin chains, removing them from substrates and thereby regulating protein turnover.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase MINDY-3 could open doors to potential therapeutic strategies. Its precise function in deubiquitinating proteins suggests a pivotal role in cellular homeostasis and protein quality control, which are essential in maintaining cellular function and preventing disease.