Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H8S9
UPID:
MOB1A_HUMAN
Alternative names:
Mob1 alpha; Mob1 homolog 1B; Mps one binder kinase activator-like 1B
Alternative UPACC:
Q9H8S9; Q53S34; Q9H3T5; Q9HAI0; Q9NVE2
Background:
MOB kinase activator 1A, also known as Mob1 alpha, Mob1 homolog 1B, and Mps one binder kinase activator-like 1B, is a crucial activator in the Hippo signaling pathway. This pathway is essential for organ size control and tumor suppression, functioning through a kinase cascade that restricts proliferation and promotes apoptosis. It activates LATS1/2, which in turn phosphorylates and inactivates the YAP1 oncoprotein and WWTR1/TAZ, preventing their nuclear translocation and the regulation of genes critical for cell proliferation, death, and migration.
Therapeutic significance:
Understanding the role of MOB kinase activator 1A could open doors to potential therapeutic strategies.