Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H8U3
UPID:
ZFAN3_HUMAN
Alternative names:
Testis-expressed protein 27
Alternative UPACC:
Q9H8U3; Q5SZZ0; Q5SZZ1
Background:
AN1-type zinc finger protein 3, also known as Testis-expressed protein 27, is a protein encoded by the gene with the UniProt accession number Q9H8U3. Its structure, characterized by the presence of AN1-type zinc finger domains, suggests a role in DNA binding and transcriptional regulation, processes crucial for cellular function and development.
Therapeutic significance:
Understanding the role of AN1-type zinc finger protein 3 could open doors to potential therapeutic strategies. Its involvement in fundamental cellular processes makes it a promising target for research aimed at uncovering novel treatments for diseases.