Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H8Y8
UPID:
GORS2_HUMAN
Alternative names:
Golgi phosphoprotein 6; Golgi reassembly-stacking protein of 55 kDa; p59
Alternative UPACC:
Q9H8Y8; B4DKT0; Q53TE3; Q96I74; Q96K84; Q9H946; Q9UFW4
Background:
Golgi reassembly-stacking protein 2, known as Golgi phosphoprotein 6, Golgi reassembly-stacking protein of 55 kDa, or p59, plays a pivotal role in the structure and function of the Golgi apparatus. It ensures the Golgi apparatus' cisternae adhere to form stacks, aligning side by side to create the Golgi ribbon. This protein, alongside GORASP1/GRASP65, is crucial for Golgi ribbon formation and maintenance, and is involved in Golgi stack reformation post-mitosis and meiosis. It also influences the transport and presentation of specific transmembrane proteins and is essential for normal spermiogenesis and male fertility.
Therapeutic significance:
Understanding the role of Golgi reassembly-stacking protein 2 could open doors to potential therapeutic strategies.