Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H9E1
UPID:
ANRA2_HUMAN
Alternative names:
RFXANK-like protein 2
Alternative UPACC:
Q9H9E1
Background:
Ankyrin repeat family A protein 2, also known as RFXANK-like protein 2, plays a crucial role in cellular processes. It is implicated in regulating the interaction between the 3M complex and histone deacetylases HDAC4 and HDAC5, as well as potentially influencing LRP2/megalin pathways. This protein's involvement in such fundamental cellular mechanisms underscores its importance in maintaining cellular homeostasis.
Therapeutic significance:
Understanding the role of Ankyrin repeat family A protein 2 could open doors to potential therapeutic strategies. Its regulatory function in key cellular processes suggests that modulating its activity could offer new avenues for treating diseases where these pathways are disrupted.