Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9HAR2
UPID:
AGRL3_HUMAN
Alternative names:
Calcium-independent alpha-latrotoxin receptor 3; Latrophilin-3; Lectomedin-3
Alternative UPACC:
Q9HAR2; E9PE04; O94867; Q9NWK5
Background:
Adhesion G protein-coupled receptor L3, also known as Latrophilin-3, plays a pivotal role in cell-cell adhesion and neuron guidance. It interacts with FLRT2 and FLRT3 on adjacent cells, facilitating the development of glutamatergic synapses in the cortex and influencing the connectivity rates between principal neurons.
Therapeutic significance:
Understanding the role of Adhesion G protein-coupled receptor L3 could open doors to potential therapeutic strategies.