Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9HC62
UPID:
SENP2_HUMAN
Alternative names:
Axam2; SMT3-specific isopeptidase 2; Sentrin/SUMO-specific protease SENP2
Alternative UPACC:
Q9HC62; B4DQ42; Q8IW97; Q96SR2; Q9P2L5
Background:
Sentrin-specific protease 2 (SENP2), also known as Axam2 and SMT3-specific isopeptidase 2, plays a pivotal role in the SUMO pathway. It is responsible for the maturation of SUMO proteins by hydrolyzing their C-terminal end and for the deconjugation of SUMO from targeted proteins, affecting various cellular processes. SENP2 also influences the Wnt pathway by modulating CTNNB1 levels, desumoylates MTA1, and stabilizes CEBPB in adipogenesis. Additionally, it regulates the cGAS-STING pathway during viral infections.
Therapeutic significance:
Understanding the role of Sentrin-specific protease 2 could open doors to potential therapeutic strategies.